15th December 2022
15th December 2022
RaNT Invited: Prof. Zachary D. Schultz
JOIN US as we kick off a new talk series inspired by Prof. Nick Stone’s £5.7 million Raman Nanotheranostics (RaNT) research programme.
In our first session, we’ll have Prof. Zachary D. Schultz from Ohio State University talking about “Super-Resolution SERS Spectral Imaging”.
This will be a hybrid talk with Prof. Schultz speaking during his visit to Exeter on 15th December.
The talk will start at 13.00 GMT and will last 45 mins + 15 mins Q&A.
Anyone unable to make the talk in-person will be able to join us virtually (sign up for the Zoom link below), and everyone will be able to ask questions at the end of the talk.
Prof. Schultz will be available to continue discussions in the Physics department SCR after the talk. Please bring your own refreshments.
SUPER-RESOLUTION SERS SPECTRAL IMAGING
Advances in nanotechnology enable the detection of trace molecules from the enhanced Raman signal generated at the surface of plasmonic nanoparticles. We have developed technology to enable super-resolution imaging of plasmonic nanoparticles, where the fluctuations in the surface enhanced Raman scattering (SERS) signal can be analysed with localization microscopy techniques to provide nanometre spatial resolution of the emitting molecule’s location. We have been able to use this approach to increase the spatial resolution of SERS imaging in living cells. While we can visualize SERS fluctuations across a wide field of view, the chemical information in these experiments generally requires a second measurement after acquiring the super-resolved image. Additional work now enables the super-resolved SERS image and the corresponding Raman spectrum to be acquired simultaneously. This spectrally resolved SERS imaging provides two spatial dimensions, a frequency dimension, and a time dimension, providing increased information characterization of molecules interacting with plasmonic nanoparticles. In this presentation, we will discuss the instrumentation, nanoparticles, and data illustrating the imaging of the Raman signal from nanoparticle probes and their use monitoring behaviour in biological cells.
Zachary D. SCHULTZ, PhD
OHIO State University
3033C McPherson Laboratory, 140 W 18th Ave, Columbus, OH 43210
Zachary D. Schultz, Ph.D., is a Professor at the The Ohio State University.
Prof. Schultz earned his B.S. degree from The Ohio State University in 2000 and Ph.D. from the University of Illinois at Urbana-Champaign in 2005. He performed his doctoral studies with Prof. Andrew Gewirth using infrared-visible sum frequency generation spectroscopy to characterize electrochemical interfaces. As a graduate student, he was recognized with an ACS Division of Analytical Chemistry Graduate Fellowship (2004).
Upon completing his Ph.D., he was awarded a National Research Council Postdoctoral Fellowship to conduct research at the National Institute of Standards and Technology (USA). His research at NIST was performed largely in collaboration with Ira Levin at the National Institutes of Health (USA). Following his postdoctoral training at NIST, Dr. Schultz continued as a research fellow at NIH using vibrational spectroscopy and microscopy to study biomembrane systems. Dr. Schultz was awarded an NIH Pathway to Independence Award in 2008.
Dr. Schultz began his independent career as an assistant professor of chemistry and biochemistry at the University of Notre Dame in 2009 and was promoted with tenure to associate professor in 2015. In January of 2018, Prof. Schultz moved his research program to Ohio State, and in 2022 was promoted to full professor.
Prof. Schultz was named a Cottrell Scholar by Research Corporation for Science Advancement in 2013, elected a fellow of the American Association for the Advancement of Science (AAAS) in 2019, and awared the Craver Award from the Coblentz Society in 2021.
Prof. Schultz has served on the Analytical Chemistry Editorial Advisory Board’s Features Panel and is currently on the Editorial Advisory board of Luminescence (Wiley) and Analytical Methods (RSC), and the Journal of Physical Chemistry A/B/C. Prof. Schultz served on the ACS Exams Institute committee to prepare the 2017 ACS Instrumental Analysis Exam. He is currently the President of the Coblentz Society, having previously served on the board of managers and chair of the Student Awards Committee.
Prof. Schultz has organized numerous symposia and sessions at Pittcon, SciX, and ACS meetings; and has served on the program committees of the International Conference for Advanced Vibrational Spectroscopy, the International Conference of Enhanced Spectroscopy, and the Tip-Enhanced Raman Scattering meetings.
Prof. Schultz’s research focuses on developing innovative approaches utilizing the unique interactions between light and nanostructured materials for near field imaging, ultrasensitive label-free spectroscopic detection, and controlling chemical reactions.
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