14th April 2023
14th April 2023
RaNT Invited: Prof. Neil Telling
JOIN US for the 2nd talk in the RaNT Invited series, inspired by Prof. Nick Stone’s £5.7 million Raman Nanotheranostics (RaNT) research programme.
This time, we’ll be joined by Prof. Neil Telling from Keele University talking about:
“A magneto-optical approach to investigate magnetisation dynamics of intracellular nanoparticles under hyperthermia conditions”.
This will be a HYBRID talk with Prof. Telling speaking during his visit to Exeter on 14th April 2023.
The talk will start at 14.00 GMT and will last 45 mins + 15 mins Q&A.
Anyone unable to make the talk in-person will be able to join us virtually (sign up for the Zoom link below), and everyone will be able to ask questions at the end of the talk.
Prof. Telling will be available to continue discussions in the Physics Department SCR (7th Floor, Physics Building) after the talk. Please bring your own refreshments.
A magneto-optical approach to investigate magnetisation dynamics of intracellular nanoparticles under hyperthermia conditions
Nanoparticle-mediated magnetic hyperthermia treatment is a promising cancer therapy that enables selective heating of cancerous tissues to slow or stop tumour growth, whilst also increasing tumour sensitivity to chemotherapy and radiotherapy. The importance of magnetic hyperthermia has fuelled interest in the development of biocompatible magnetic nanomaterials. However, previous experiments have suggested that the association of nanoparticles with cells modifies their magnetic response, thus dramatically altering heating efficiency. To explain this behaviour and inform on new design configurations for intracellular hyperthermia, the development of new characterisation tools capable of assessing nanoparticles under relevant biological conditions is required.
In this talk I will present a novel in-house developed magneto-optical microscope based on the Faraday effect, that enables the study of magnetisation dynamics of nanoparticles in cellular environments under hyperthermia conditions, in combination with fluorescence measurements. The system is capable of mapping localised AC magnetic susceptibility, magnetometry and fluorescence (amplitude and lifetime), under magnetic fields generated at frequencies up to 1 MHz for AC susceptibility (500 kHz for AC magnetometry), and amplitudes of up to 50 mT (dependent on frequency). The intracellular magnetic properties can be probed in situ with <1 μm resolution, and the system can also be used to probe nanoparticles in liquid suspensions. I will present direct observations revealing the influence of cellular environment on the AC magnetic properties of nanoparticles in both fixed and living cancer cells. Sub-micron measurements of magnetization dynamics are discussed, as well as the first demonstration of AC susceptibility microscopy. Crucially, these experiments reveal huge variability as a function of nanoparticle cellular location and AC field frequency, demonstrating the importance of this new optical approach for understanding the magnetic behaviour of intracellular nanoparticles for hyperthermia.
Neil TELLING, PhD
Professor of Biomedical NanoPhysics & Research Director
School of Pharmacy and Bioengineering, Guy Hilton Research Centre, Thornburrow Drive, Stoke-on-Trent ST4 7QB, United Kingdom
Neil Telling is a Professor in Biomedical NanoPhysics at the University of Keele.
He started his research career studying the physical and magnetic properties of thin films and multilayers for advanced data storage devices. Subsequently the focus of his research has evolved and now centres around the investigation and application of nanoscience in biomedical areas. This includes developing a better understanding and control of the properties of magnetic nanoparticles in fluid suspension, as well as investigating how these properties change following the interaction of the nanoparticles with biological environments (for example after their association with cells).
Working with multidisciplinary groups that include chemists, biologists, and clinicians, his research targets the development of new methods and materials for nanotechnology-based biomedical treatments.
Current projects include magnetic nanoparticle hyperthermia for cancer therapy, and magneto-mechanical based methods for applications in regenerative medicine.
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